We have five support-users in Kayako. If we have an end-user send an email to
support@domain.com, it creates a ticket. If the alerts are setup to notify all support-users of both new tickets and new replies -- it then sends out an email to all five users.
However, whether it is a new ticket alert or a new reply alert, and one of the five of us have an out-of-office message (that responds to every email) -- it then generates an addition to the ticket and then generates another round of "new reply alerts" to the five .. and then it happens again.
(Luckily only limited to 1 every 5 minutes because the email queue is only checked once every 5 minutes).